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Relations between local microflow and tissue pressure in oxygen of the cerebral cortex in the awake rabbit (1 figure)

par Manil, Jacqueline ;Coremans, Jean;Colin, Frédéric ;Bourgain, René
Référence Archives of physiology and biochemistry, 92, 2, page (P1-P2)
Publication Publié, 1984

Article révisé par les pairs

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Résumé :

Previous experiments (Manil et al., 1983) have revealed spontaneous oscillations of the cortical tissue pressure in oxygen (CTpO2) in a frequency band going from 0.03 to 0.33 Hz. No correlation could be found with the fluctuations of the systemic blood pressure except in stress situation. These oscillations were still present even after the spontaneous electrocortical activity had completely disappeared as a result of deep barbiturate anaesthesia. It was shown that these oscillations had to be attributed to circumscribed areas of the cerebral cortex of about 2 mm. Maximal vasodilation induced by breathing 5% CO2 increased and stabilized the CTpO2. Pharmacological analysis showed that alpha-blocking agents tremendously enhanced this otherwise spontaneous phenomenon. It was thus tempting to attribute this phenomenon to some vasomotor mechanisms. However, it remained to be shown that the oscillations of the CTpO2 were linked to fluctuations of the local microflow. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.