Antibody response of immunodeficient (xid) CBA/N mice to Escherichia coli 0113 lipopolysaccharide, a thymus-independent antigen

Hiernaux, Jacques Rene; Jones, Janet M B J.M.; Rudbach, Jon J.A.; Rollwagen, Florence; Baker, Phillip P.J.

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Antibody response of immunodeficient (xid) CBA/N mice to Escherichia coli 0113 lipopolysaccharide, a thymus-independent antigen

par Hiernaux, Jacques Rene

;Jones, Janet M B J.M.;Rudbach, Jon J.A.;Rollwagen, Florence ;Baker, Phillip P.J.
Référence The Journal of experimental medicine, 157, 4, page (1197-1207)
Publication Publié, 1983

Article révisé par les pairs

Résumé :

CBA/N mice, which posses an X-linked immunodeficiency (xid), produce a convincing antibody response to lipopolysaccharide derived from Escherichia coli 0113 (LPS 0113), a thymus-independent antigen. The antibody response produced was shown to be specific for the O-polysaccharide moiety of LPS 0113, rather than lipid A or lipid-A-associated protein. The relevance of this finding to the nature of the genetic defect of xid-mice is discussed.

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