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Synthesis, characterization and antitumour activity of 7,7-di-n-butyl-5,9-dioxo-6,8-dioxa-7-stanna-spiro[3,5]nonane, a di-n-butyltin(IV) analog of "paraplatin", and of a series of di-n-butyltin(IV) derivatives of mono- and disubstltuted malonic acids

par Gieten, Marcel;Metotte, Munel;Atassi, Ghanem ;Willern, Rudolph
Référence Tetrahedron, 45, 4, page (1219-1229)
Publication Publié, 1989

Article révisé par les pairs

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Résumé :

Cis-diammine[1,1-cyclobutanedicarboxylatol]platinum(II) ("carboplatin" or "paraplatin") is a therapeutic agent clinically used against some cancers. Because several diorganotin(IV) derivatives do exhibit antitumour properties, we have prepared and characterized 7,7-di-n-butyl-5,9-dioxo-6,8-dioxa-7-stanna-spiro[3,5] nonane, compound 1, a di-n-butyltin(IV) analog of "paraplatin". To determine if the spiro structure or/and the presence of the four-membered ring is important for the antitumour activity, we have also prepared and characterized a series of di-n-butyltin(IV) derivatives of mono- and disubstituted malonic adds. Compound 1 did not show any significant anti-tumour activity in vivo against L1210 leukemia in mice. © 1989.