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Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity.

par Sebastiani, Guido;Grieco, Fabio Arturo ;Spagnuolo, Isabella;Galleri, Letizia;Cataldo, Dorica;Dotta, Francesco
Référence Diabetes/metabolism research and reviews, 27, 8, page (862-866)
Publication Publié, 2011-11

Article révisé par les pairs

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Résumé :

The current paradigm that microRNAs represent a new layer of gene regulation has generated much interest in this field. MicroRNAs have emerged as important regulatory factors involved in the developmental processes and in the regulation of insulin secretion and signalling. Furthermore, recent studies revealed an altered microRNA profiling in lymphocytes of patients with autoimmune diseases like multiple sclerosis, in which a hyperexpression of miR-326 was reported. Here, we analysed the expression levels of miR-326 in peripheral blood lymphocytes from type 1 diabetic (T1D) patients in relationship with ongoing islet autoimmunity.