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Delta-cell-specific expression of hedgehog pathway Ptch1 receptor in murine and human endocrine pancreas.

par Grieco, Fabio Arturo ;Moretti, Marta;Sebastiani, Guido;Galleri, Letizia;Spagnuolo, Isabella;Scafetta, Gaia;Gulino, Alberto;De Smaele, Enrico;Maroder, Marella;Dotta, F
Référence Diabetes/metabolism research and reviews, 27, 8, page (755-760)
Publication Publié, 2011-11

Article révisé par les pairs

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Résumé :

Hedgehog pathway plays an important role during pancreas development, when its inactivation is crucial to assure expression of pancreatic marker genes involved in the organ formation and to assure an appropriate organogenesis. Patched1 (Ptch1) is a transmembrane receptor of hedgehog pathway which has a key role in this process. In fact, heterozygous Ptch1 mutant (ptc+/-) mice are affected by an impaired glucose tolerance accompanied by reduced islet function. In the light that the cell distribution of Ptch1 receptor within the endocrine pancreas has not yet been established, we aimed at identifying the pancreatic endocrine cell subset(s) expressing such molecule.