par Marchetti, Piero;Lupi, R.;Bugliani, M;Kirkpatrick, C L;Sebastiani, Guido;Grieco, Fabio Arturo 
;Del Guerra, Silvia;D'Aleo, Valentina;Piro, Salvatore;Marselli, L;Boggi, U;Filipponi, F;Tinti, Laura;Salvini, Laura;Wollheim, C B;Purrello, Francesco;Dotta, F
Référence Diabetologia, 55, 12, page (3262-3272)
Publication Publié, 2012-12
;Del Guerra, Silvia;D'Aleo, Valentina;Piro, Salvatore;Marselli, L;Boggi, U;Filipponi, F;Tinti, Laura;Salvini, Laura;Wollheim, C B;Purrello, Francesco;Dotta, FRéférence Diabetologia, 55, 12, page (3262-3272)
Publication Publié, 2012-12
Article révisé par les pairs
| Résumé : | Glucagon-like peptide 1 (GLP-1) is a major incretin, mainly produced by the intestinal L cells, with beneficial actions on pancreatic beta cells. However, while in vivo only very small amounts of GLP-1 reach the pancreas in bioactive form, some observations indicate that GLP-1 may also be produced in the islets. We performed comprehensive morphological, functional and molecular studies to evaluate the presence and various features of a local GLP-1 system in human pancreatic islet cells, including those from type 2 diabetic patients. |
