• Citer

Diorganotin difluorobenzoates: synthesis, spectroscopic characterization and in vitro antitumour activity. X-Ray structure determination of bis[di-n-butyl(2,6-difluorobenzoato)tin] oxide

par Gielen, Marcel ;Biesemans, Monique;El Khloufi, Abdelaziz;Meunier-Piret, Jacqueline;Kayser, François;Willem, Rudolph
Référence Journal of fluorine chemistry, 64, 3, page (279-291)
Publication Publié, 1993

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

The synthesis and spectroscopic characterization of diorganotin(IV) bis(difluorobenzoates) [F2C6H3COO]2SnR2 [type a] and bis[diorgano(difluorobenzoato)tin(IV)] oxides {[(F2C6H3COO)R2Sn]2O}2 [type b] are described. An X-ray structure study has revealed compound 3b, {[(2,6-F2C6H3COO)(n-C4H9)2Sn]2O}2, to be dimeric and built around a planar Sn2O2 ring. The crystals are triclinic P1 with the cell dimensions a = 11.935(13), b = 12.3675(14), c = 12.974 Å, α = 92.89(8), β = 84.32(7), γ = 67.49(9)°; Z = 1, with the dimer being centro-symmetric. Selected compounds have been tested in vitro against two human tumour cell lines, MCF-7 (a mammary tumour) and WiDr (a colon carcinoma), and exhibit promising cytotoxicities. © 1993.