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Enhancement by succiic acid dimethyl ester of insulin release evoked by d-glucose and glimepiride in the perfused pancreas of normoglycemic and hyperglycemic rats

par Leclercq Meyer, Viviane ;Malaisse, Willy
Référence Biochemical pharmacology, 47, 9, page (1519-1524)
Publication Publié, 1994-04

Article révisé par les pairs

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Résumé :

The present study deals with the insulinotropic action of the dimethyl ester of succinic acid (SAD), considered as a potential tool for the treatment of non-insulin-dependent diabetes mellitus. In the perfused pancreas prepared from either euglycemic rats or animals first infused for 48 hours with a solution of d-glucose, SAD (10mM) markedly enhanced insulin output evoked by a high concentration of d-glucose (16.7 mM), whether in the absence or presence of glimepiride (0.5μM). The succinate ester failed, however, to affect glucagon secretion. Thus, SAD indeed displays favourable attributes for stimulation of insulin release in type 2 diabetes, with emphasis on its insulinotropic efficiency at high concentrations of d-glucose in an animal model of B-cell glucotoxicity. © 1994.