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Theoretical and practical importance of plasma levels of haloperidol. correlations with clinical and computerized EEG data

par De Buck, René ;Zelaschi, Norberto;Gilles, Christian ;Durdu, Jacques ;Brauman, Henri
Référence Progress in Neuro-Psychopharmacology, 5, 5-6, page (499-502)
Publication Publié, 1981

Article révisé par les pairs

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Résumé :

1. 1. Haloperidol plasma levels, after long acting haloperidol i.m. injection, are analyzed and compared with clinical evolution and EEG modifications. 2. 2. Haloperidol plasma levels were determined by radioimmunoassay. Clinical status was assessed weekly and computerized EEG were performed daily from day 3 to 7 after haloperidol decanoate injection. 3. 3. The plasma level-dose relationship during oral treatment and 4 weeks after haloperidol decanoate injection are very similar. After injection, the plasma level attains its highest value within 3 to 10 days and decreases along a logarithmic curve. An inverse relationship with B.P.R.S.scores is found in many patients. EEG changes are related to clinical status rather than to plasma levels. 4. 4. The results obtained by these three methods are proposed as criteria for the assessment of the reinjection time. © 1981.