A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe
par Mocroft, Amanda;Phillips, Andrew N.;Reiss, Peter;Rakhmanova, Aza;Banhegyi, Dénes;De Wit, Stéphane
;Ristola, Matti;Lundgren, Jens D;Grarup, Jesper;Kirk, Ole
Référence Infection, 42, 4, page (757-762)
Publication Publié, 2014
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Référence Infection, 42, 4, page (757-762)
Publication Publié, 2014
Article révisé par les pairs
Résumé : | ATRIPLA is licensed for use only in HIV-positive persons whose viral loads <50 for ≥3 months. We investigated the use of ATRIPLA as first-line antiretroviral therapy (ART) in EuroSIDA using a web-based survey performed in Autumn 2012. 96/112 clinics (85.7 %) completed the survey. Recommendations when initiating first-line ART was TRUVADA plus efavirenz in 36 (37.5 %), ATRIPLA in 35 (36.5 %), a different first-line regimen in 12 clinics (12.5 %), and no recommendation in 7 clinics (7.3 %). ATRIPLA was commonest in Northern (15/21 clinics; 71.4 %), and least common in Eastern Europe (2/31 clinics; 6.5 %; p < 0.0001). Over one-third of the participating clinics in this survey were using ATRIPLA as first-line antiretroviral therapy, despite EMA recommendations. © 2014 The Author(s). |