par Kelecom, Alphonse ;Daloze, Désiré ;Tursch, Bernard
Référence Tetrahedron, 32, 19, page (2353-2359)
Publication Publié, 1976
Référence Tetrahedron, 32, 19, page (2353-2359)
Publication Publié, 1976
Article révisé par les pairs
Résumé : | Aqueous hydrochloric acid hydrolysis of the mixture of thelothurins A and B, the saponins from the sea cucumber Thelonota ananas Jaeger, gave a complex mixture from which six sapogenins were isolated. Chemical and spectroscopic evidence led to the assignment of structures 3-8 to these genins which are correlated to the known seychellogenin acetate (9). It is also shown that compounds 1 and 2, obtained by mild aqueous acetic acid hydrolysis of the thelothurins, are the genuine aglycones, whereas 3-8 are artifacts. Their formation during the hydrolysis of the saponins is discussed. The aglycone moiety of thelothurins A (20A) and B (20B) was biosynthesized from the acetate. © 1976. |