par Maruyama, Hidekazu;Dewachter, Céline ;Belhaj, Asmae ;Rondelet, Benoît ;Sakai, Satoshi;Remmelink, Myriam ;Vachiery, Jean-Luc ;Naeije, Robert ;Dewachter, Laurence
Référence The Journal of heart and lung transplantation
Publication Publié, 2014-09
Référence The Journal of heart and lung transplantation
Publication Publié, 2014-09
Article révisé par les pairs
Résumé : | Endothelin receptor antagonists improve pulmonary arterial hypertension (PAH). Mutations in the bone morphogenetic protein (BMP) type 2 receptor (BMPR2) predispose to PAH. Here, we sought to determine whether there might exist interactions between these 2 signaling pathways and their effect on the acquisition of the altered phenotype of pulmonary artery smooth muscle cells (PA-SMCs) observed in PAH. |