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Efficient formation of aromatic thiols from thiomethylated precursors

par Pinchart, Alain;Dallaire, Carol ;Van Bierbeek, Alain;Gingras, Marc
Référence Tetrahedron letters, 40, 30, page (5479-5482)
Publication Publié, 1999-07

Article révisé par les pairs

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Résumé :

As a model study, a series of linear and branched p-phenylene and m- phenylene sulfides, functionalized by a thiomethyl group, were deprotected to thiols while using various alkyl thiolates at 160°C in DMF. Many complex aromatic thiols were obtained in almost quantitative yields from a trivial purification and without significant contamination by disulfides. This methodology is reliable, efficient and has been optimized on several substrates.