par Humblet, Christine;De Coen, Jean-Louis 
Référence International journal of biological macromolecules, 3, 1, page (37-45)
Publication Publié, 1981-02
Référence International journal of biological macromolecules, 3, 1, page (37-45)
Publication Publié, 1981-02
Article révisé par les pairs
| Résumé : | Results of an extensive theoretical conformational analysis of the opiate pentapeptide Met5-enkephalin are compared to spectroscopic data. The comparison enables us to propose a consistent model for the conformational state of Met5-enkephalin in solution. The empirical energy calculations suggest that the molecule exists in aqueous solution in a small number of folded and extended families of conformers. The predominance of βII′-turns at the level of the glycine residues at positions 2 and 3 is the most significant characteristic of folded conformers. A highly populated conformer of Met5-enkephalin is shown to possess structural features in common with the very potent narcotic etonitazene. © 1981. |
