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Studies on inhibitors of skin-tumor promotion. Inhibitory effects of triterpenes from Cochlospermum tinctorium on epstein-barr virus activation

par Diallo, Bilo ;Vanhaelen, Maurice ;Vanhaelen Fastré, Renée ;Konoshima, Takao;Kozuka, Mutsuo;Tokuda, Harukuni
Référence Journal of natural products, 52, 4, page (879-881)
Publication Publié, 1989

Article révisé par les pairs

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Résumé :

Arjunolic acid, an oleanene-type triterpene isolated from the rhizome of Cochlospermum tinctorium, its triacetate derivative, and their methyl esters were tested using the short-term in vitro assay on EBV-EA activation in Raji cells induced by 12-0-tetradecanoyl-phorbol-13-acetate (TPA). Their inhibitory effects on skin tumor promoters were found to be greater than those of previously studied natural products.