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Hydrocortisone prevents the increases in permeability and PGE synthesis induced by endotoxin in the isolated rat mesentery

par Kahn, André ;Brachet, Etienne
Référence Archives of physiology and biochemistry, 92, 2, page (P12-P13)
Publication Publié, 1984

Article révisé par les pairs

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Résumé :

We have shown earlier that endotoxin (ETX) increases the permeability coefficient of albumin (PA), and the synthesis of prostaglandin E (PGE) in the rat mesentery (Brachet & Kahn, 1981). As these effects could be inhibited by indomethacin, we had suggested that most, if not all, of the early actions of endotoxin in the mesentery could be ascribed to the local triggering of PGE synthesis. The present experiments were designed as a complement to those cited above. We investigated whether hydrocortisone (HC) might also block the rises in PA and PGE production, induced by ETX. Glucocorticoids eventually inhibit phospholipase A2 (Flower, 1981). and block PG synthesis through other mechanisms than indomethacin. © 1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.