par Famaey, Jean Pierre ;Whitehouse, Michael Wellesley
Référence Archives of physiology and biochemistry, 86, 3, page (577-591)
Publication Publié, 1978
Référence Archives of physiology and biochemistry, 86, 3, page (577-591)
Publication Publié, 1978
Article révisé par les pairs
Résumé : | Glyco- and tauro-deoxycholate, -chenodeoxycholate, -dehydrocholate and -cholate uncouple the mitochondrial oxidative phosphorylation in this order of potency. They also induce pseudo-energized mitochondrial swelling and lymphocyte swelling in the same order of potency. Similar swelling properties were observed for glyco- and tauro-lithocholate. Glyco- and tauro-deoxycholate induce alkalinization of the intra-mitochondrial space as determined on bromothymol blue pre-loaded mitochondria. These two bile salts conjugates also increase the amount of -SH groups available on lymphocyte membranes for sulfhydryl-disulfide interchange reactions. All these biochemical properties have been described for non-steroidal anti-inflammatory drugs. They could thus be implicated in the jaundice remission observed in various inflammatory states. © 1978 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |