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Evolutionary divergence of genes for ornithine and aspartate carbamoyl-trasferases-complete sequence and mode of regulatio of the Escherichia coli argF gene; comparison of argf with argI and pyrB

par Van Vliet, Françoise ;Cunin, Raymond ;Jacobs, Annemie;Piette, Jacques;Glansdorff, Nicolas ;Lauwereys, Marc;Gigot, Daniel ;Pierard, André
Référence Nucleic acids research, 12, 15, page (6277-6289)
Publication Publié, 1984-08

Article révisé par les pairs

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Résumé :

The complete nucleotide sequence of argF is presented, together with that of an operator-constitutive mutant. ArgF is compared with the other gene coding for ornithine carbamoyltransferase (OTCase) in E. coli K-12, argI, and with pyrB, encoding the catalytic monomer of aspartate carbamoyltransferase (ATCase). ArgF and argI appear very closely related having emerged from a relatively recent ancestor gene. The relationship between OTCase and ATCase appears more distant. Nevertheless, the homology observed between the two proteins (mainly in the polar domain) suggests a common origin. © 1984 IRL Press Limited.