par Zagury, Jean-François;Achour, Ammar;Astgen, A.;Lachgar, Abderrahim;Fall, LS;Carelli, Claude;Issing, Wolfgang;Mbika, JP;Cantalloube, Hubert M J H.;Zagury, Daniel;Bernard, Jacky;Picard, Odile;Gourbil, Anne;Guignon, J.M. J.M.;Cozette, J.;Faure, Jeán Pierre;Biou, Daniel;Carlotti, M.;Bizzini, Bernard;Callebaut, Isabelle;Mornon, Jean Paul;Burny, Arsène 
;Feldman, Michael
Référence Biomedicine & pharmacotherapy, 47, 2-3, page (93-99)
Publication Publié, 1993
;Feldman, MichaelRéférence Biomedicine & pharmacotherapy, 47, 2-3, page (93-99)
Publication Publié, 1993
Article révisé par les pairs
| Résumé : | We have previously unravelled the striking SLWDQ pentapeptide identity between HIV-1 env gp120 and the CD4 molecule. We show here that this pentapeptide is required for the functioning of the co-stimulatory MHC-CD4 signal in T4-cell activation since it suppresses antigen-induced T-cell proliferation. Moreover, concerning the MHC class II counterpart, the LNGQEETGVVSTN sequence which strongly inhibits T-cell immune activation is likely to be part of the functional site of the molecule. Interestingly the MHC/gp120 homology described by Young overlaps this MHC region. We further report that the gp120 SLWDQ peptide triggers an immune reaction which is both humoral (anti-SLWDQ antibodies) and cellular (CTLs against autologous targets carrying the pentapeptide) in HIVA infected individuals. Finally, anti-SLWDQ antibodies from patients sera purified by column chromatography strongly inhibit antigen-induced immune T-cell activation. This result led us to postulate that these antibodies found in high titers in HIVA infected individuals could contribute to set up the progressive systemic immune T-cell suppression characterizing AIDS. © 1993. |
