Article révisé par les pairs
Résumé : Background and study aims: To determine long-term outcome after treatment with an intra-gastric balloon for 6months, with no structured weight maintenance program offered after balloon removal. Patients and methods: 100 consecutive overweight/obese individuals (mean body mass index [BMI] 35.0±5.6kg/ m2) were prospectively fol-lowed after endoscopic implantation of a saline filled intragastric balloon; 97 completed final -follow-up at a mean of 4.8±1.6years. Success-ful intragastric balloon therapy was defined as weight loss at 6 months of ≥ 10% of weight at -baseline, that remained ≥ 10% until 2.5years, with-out bariatric surgery. All analyses followed intention-to-treat principles. Results: At 6months, mean weight loss was 12.6±8.3kg, 63 individuals had ≥ 10% baseline weight loss; no severe morbidity was detected. During the first and second years following intragastric balloon removal, mean body mass in-creased by 4.2±6.8 and 2.3±6.0kg, respectively (P<0.001 for both year-on-year comparisons). At 2.5years, intragastric balloon therapy had been successful in 24 participants. At final follow-up (4.8±1.6years), 28 had ≥ 10% baseline weight loss, 35had undergone bariatric surgery (60% had preoperative mass higher than baseline), and 3were lost to follow-up; the 34remaining had lost 1.5±5.8kg compared with baseline. During follow-up, 13 had a second intragastric balloon implanted and 13 took sibutramine for short -periods. Conclusion: Intragastric balloon therapy was relatively innocuous and associated with successful weight loss and maintenance at 2.5years in a quarter of participants. It represents a valid op-tion for weight loss. © Georg Thieme Verlag KG Stuttgart - New York.

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