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Broncho-alveolar Lavage (BAL) for the diagnosis of sarcoidosic uveitis

par Caspers, Laure ;Makhoul, Dorine;Willermain, Francois ;Ebraert, Herlinde;Michel, Olivier
Référence Ocular immunology and inflammation, 22, 2, page (102-109)
Publication Publié, 2014

Article révisé par les pairs

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Résumé :

Purpose: To evaluate the use of BAL for the diagnosis of sarcoidosic uveitis. Methods: Retrospective study of 109 consecutive patients with uveitis and minimum 2 signs of ocular sarcoidosis who had a BAL and chest imaging. BAL+ was defined as an alveolar (a) lymphocytosis (L) aL>15% with aCD4/CD8>3.5. Serum angiotensin converting enzyme (sACE), tuberculin skin test and gallium scan were tested in 83, 95 and 24 patients. Results: BAL was + in 26.6% of patients (86.2% females, mean age 50.8y) with mean aL=46.8% and mean aCD4/CD8=8.5 which significantly differed form BAL- patients: 62.5% females, p<0.02, mean age 43.6y, p<0.05, mean aL=17.2%, p<0.001 and mean aCD4/CD8=1.8, p<0.001. BAL+ patients had 31% of bilateral hilar adenopathy (BHL+), and 59.1% of elevated sACE which significantly differed form BAL- patients: 8.8%, p=<0.01 and 14.8% p<0.001. Conclusion: Our findings suggest that BAL have a high diagnostic value and might be a useful additional test for the diagnosis of sarcoidosic uveitis, even with normal chest imaging. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.