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Cis-platinum as second-line chemotherapy in advanced gastric adenocarcinoma. A phase II study of the EORTC gastrointestinal tract cancer cooperative group

par Lacave, Ángel Jiménez;Wils, Jaques;Díaz-Rubio, Eduardo;Clavel, Michel;Planting, André S Th A.;Bleiberg, Harry ;Duez, Nicole;Dalesio, Otilia
Référence European journal of cancer & clinical oncology, 21, 11, page (1321-1324)
Publication Publié, 1985

Article révisé par les pairs

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Résumé :

Thirty-four patients with measurable metastatic gastric adenocarcinoma refractory to prior chemotherapy were treated with cis-platinum 100 mg/m2 in a 6-hr infusion at 3-week intervals. Thirty-one patients were evaluable for response. There were three complete and three partial responses. Median duration of response was 4 months. Toxicity consisted mainly of nausea and vomiting and was severe in 12 patients. One patient had a severe but reversible renal failure. These results confirm other data reported in the literature. Cis-platinum has activity in gastric adenocarcinoma and should now be further investigated in first-line chemotherapy. © 1985.