par Mardens, Yves Léonce 
;Kumps, Alain ;Planchon, Catherine ;Wurth, Claudine
Référence Journal of Chromatography B: Biomedical Sciences and Applications, 577, 2, page (341-346)
Publication Publié, 1992-06
;Kumps, Alain ;Planchon, Catherine ;Wurth, ClaudineRéférence Journal of Chromatography B: Biomedical Sciences and Applications, 577, 2, page (341-346)
Publication Publié, 1992-06
Article révisé par les pairs
| Résumé : | We have compared a new isolation procedure for urinary organic acids using strong anion-exchange columns with a solvent partition (ethyl acetate) method. Urinary samples from two healthy children and from nine children with organic acidurias were analysed by both procedures. Although the solid-phase extraction is more efficient for polyhydroxy acids, some polar acids, and some glycine derivatives, clinically important compounds such as oxalic, methylcitric, pyruvic, glyoxylic and 2-ketoglutaric acids, are not recovered or are only poorly recovered. However, both procedures may be used as a routine method for the diagnosis of the organic acidurias included in this study. © 1992. |
