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The antitumoral activity of some derivatives of 6-aminochrysene

par Tagnon, Henri ;Coune, André ;Garattini, Sylvio;Rosso, Ronal;Lambelin, Georges;Gautier, M.;Buu-Hoï, Nguyen N.P.
Référence European journal of cancer, 6, 2, page (81-87)
Publication Publié, 1970

Article révisé par les pairs

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Résumé :

Twenty-two N-substituted derivatives of the carcinostatic 6-aminochrysene have been tested as potential carcinostatic agents (using 6-aminochrysene as a standard) on spontaneous mammary tumor in [C3H/020] F1 mice, and on the slow-growing transplanted rhabdomyosarcoma in inbred WAG/Rij rats. Many of these compounds displayed important activity against both types of tumor, and some of them merit further investigations. In contrast compounds active on these experimental tumors, were completely inactive on Ehrlich carcinoma and on Sarcoma 180. © 1970.