par Delince, Philippe 
;Willems, Glenda ;De Graef, Jacques
Référence Digestion, 18, 1-2, page (27-34)
Publication Publié, 1978
;Willems, Glenda ;De Graef, Jacques Référence Digestion, 18, 1-2, page (27-34)
Publication Publié, 1978
Article révisé par les pairs
| Résumé : | The total number of antral gastrin cells, the antral surface area and the serum gastrin concentration were determined in two groups of rats. The animals had been submitted at random either to vagotomy and pyloroplasty or to pyloroplasty alone 3 weeks before. The indirect immunoperoxidase reaction and a direct quantitative histological method were used to count the gastrin cells. Radioimmunoassay was used to estimate the serum gastrin concentration. The total number of gastrin cells in the stomach was 52% (p < 0.01) more elevated in the vagotomized animals. Both antral mucosal surface and calculated concentration of gastrin cells per square millimeter of mucosa were significantly higher (0.01 < p < 0.05) in this group of animals. The serum gastrin values were significantly (p < 0.01) more elevated after vagotomy. These observations indicate that vagotomy may induce an antral gastrin cell hyperplasia which could explain in part the hypergastrinemia observed after this surgical procedure. |
