• Citer

Synthesis of high affinity antibodies in irradiated rabbits grafted with allogeneic cells from hyperimmune donors

par Van Acker, Annette;Vansanten, Georgette ;De Vos-Cloetens, Christine ;Tasiaux, Nicole
Référence Annales d'immunologie, 130, 3, page (385-396)
Publication Publié, 1979

Article révisé par les pairs

• Détails
• Contenu

Résumé :

Irradiated rabbits grafted with allogeneic lymph node, spleen and bone marrow cells from a donor rabbit hyperimmunized against tobacco mosaic virus synthesize high affinity antibodies, displaying mainly recipient allotypic specificities, after antigen boosting. By contrast, recipient rabbits from non-immune donors synthesize antibodies of lower affinity. It is suggested that the differentiation of new emerging host B cells is specifically influenced by the presence of donor-memory cells.