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Action de la ribonucléase sur la croissance néoplasique V. Aspects métaboliques de l'effet cancérostatique

par Ledoux, Lucien ;Vanderhaeghe, Francine
Référence Biochimica et biophysica acta (G). General subjects, 24, C, page (340-353)
Publication Publié, 1957

Article révisé par les pairs

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Résumé :

In the cells of ascites tumours (Landschütz) ribonuclease causes, both in vivo and in vitro, a rapid alteration in the metabolism of ribonucleic acid. The rates of incorporation of adenine and of guanine are modified only slightly or not at all, whereas those of uracil and cytosine are considerably increased (more than 100%). Thus the metabolism of the pyrimidines is greatly accelerated in the presence of RNase. Moreover, the metabolism of the thymine of ADN is disturbed. It also seems that under these, conditions, i.e. during the first stage of the action, the metabolism of the proteins is not modified. Our results indicate that RNase causes the rapid appearance of an abnormal ribonucleic acid and that the carcinostatic action of this enzyme must be sought in the imbalance of the metabolism of the nucleic acids. © 1957.