Mechanism of action of cyclosporin in rheumatoid arthritis

Bentin, Jacques

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Mechanism of action of cyclosporin in rheumatoid arthritis

par Bentin, Jacques

Référence Clinical rheumatology, 14, SUPPL. 2, page (22-25)
Publication Publié, 1995

Article révisé par les pairs

Résumé :

Heterogenous population of cells, including macrophages, synoviocytes and lymphocytes play important roles in the immunopathogenesis of rheumatoid arthritis (RA). T cells, however, seem to be a common thread throughout the disease process. In inhibiting T lymphocytes, cyclosporin A presents a more selective form of therapy in RA. The immunosuppressive action of cyclosporin is primarily due to the inhibition of antigen/mitogen-induced secretion of lymphokines at the transcriptional level from T cell. The inhibition of Ca2+-dependent signaling pathways by cyclophilin-cyclosporin complexes in T cell appears to shut down lymphokine-gene transcription.

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