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Combination chemotherapy with three marginally effective agents, CCNU, vincristine, and bleomycin, in the treatment of stage III melanoma

par De Wasch, Gilbert;Bernheim, Jan;Michel, Jeffrey;Lejeune, Ferdinand ;Kenis, Yvon
Référence Cancer treatment reports, 60, 9, page (1273-1276)
Publication Publié, 1976

Article révisé par les pairs

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Résumé :

42 patients with stage III melanoma were treated with a combination of CCNU, bleomycin, and vincristine. 17 of 35 evaluable patients achieved an objective response (48.5%) including 5 patients with CRs. The median duration of response was 4 mth (range 1-18 mth). The responders had a median survival of 278 days (range, 78-1100 days) and the nonresponders had a median survival of 168 days (range, 34-619 days). The toxicity of the combination was within an acceptable range with no toxic deaths.