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The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy: The QLQ-CIPN20

par Postma, Tjeerd J B M T.J.;Heimans, Jan J.J.;Aaronson, Neil;Muller, Martin M.J.;Hildebrand, Jerzy ;Delattre, Jean-Yves;Hoang-Xuan, Khê;Lantéri-Minet, Michel;Grant, Robin;Huddart, Robert;Moynihan, Clare;Maher, Jane;Lucey, R.
Référence European journal of cancer, 41, 8, page (1135-1139)
Publication Publié, 2005-05

Article révisé par les pairs

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Résumé :

Chemotherapy-induced peripheral neuropathy (CIPN) is a common phenomenon, often resulting in serious limitations in daily functioning and comprosised quality of life. Currently available toxicity grading systems typically use a combination of clinical and paraclinical parameters and relies on the judgment of clinicians and/or nurses. However, because many of the symptoms of CIPN are subjective in nature, it is only logical that an assessment of CIPN be based, at least in part, on patient self-report data. We report on the development of a patient self-report questionnaire, the CIPN20, intended to supplement the core quality of life questionnaire of the European Organization for Research and Treatment of Cancer (EORTC). Following EORTC guidelines, relevant CIPN-related issues were identified from a literature survey and interviews with health professionals (n = 15) and patients (n = 112). The resulting 20-item questionnaire was pre-tested in three languages and four countries and is currently being examined in a large, international clinical trial. The EORTC CIPN20 should provide valuable information on CIPN-related symptoms and functional limitations of patients exposed to potentially neurotoxic chemotherapeutic and/or neuroprotective agents. © 2005 Elsevier Ltd. All rights reserved.