par Herzog, Albert 
Référence Biochemical and biophysical research communications, 15, 2, page (172-176)
Publication Publié, 1964-03
Référence Biochemical and biophysical research communications, 15, 2, page (172-176)
Publication Publié, 1964-03
Article révisé par les pairs
| Résumé : | It has been suggested by Spotts and Stanier (1961) that the primary site of action of streptomycin (Sm) is the ribosomes. According to their hypothesis, the different alleles at the streptomycin locus would direct the synthesis of structurally different ribosomes, and this would be responsible for sensitivity (Sms), resistance (Smr) or dependence (Smd) towards the antibiotic. This hypothesis was reinforced by reports from several laboratories (Flaks et al., 1962; Mager et al., 1962;Speyer et al., 1962) that in cell-free amino acids incorporating systems, streptomycin exerts a strong inhibitory effect, when the ribosomal fraction has been purified from a Sms strain, but that it has only a small effect when the ribosomes originate from Smr or Smd bacteria. The aim of this work was to look for a possible effect of streptomycin on the centrifugation patterns of ribosomes, using a Sms and a Smr strain of E. coli. © 1964. |
