par Willems, Glenda ;Vansteenkiste, Y.;Smets, Philippe
Référence American Journal of Digestive Diseases, 16, 12, page (1057-1063)
Publication Publié, 1971-12
Article révisé par les pairs
Résumé : A sequential analysis of the proliferative parameters was performed in the canine fundic mucosa after instillation of alcohol. Mucosal specimens obtained at 4-hour intervals through a gastric cannula, were incubated with tritiated thymidine and submitted to autoradiographic procedure. After ethanol, significant variations were observed in the labeling index, mitotic index and in foveolar height. Foveolar height was abruptly reduced at the fourth hour. The labeling index was increased between the eighth and the twentieth hour, whereas a mitotic peak appeared between the twentieth and the twenty-fourth hour and, quite simultaneously, the mucosal pattern was restored to normal. This demonstrates that when alcohol instilled into the stomach, a burst of proliferative activity occurs, which might be related to a regenerative process. © 1971 Hoeber Medical Division • Harper & Row, Publishers, Incorporated.