par Hainaut, Karl ;Desmedt, Jean Edouard
Référence Nature (London), 252, 5485, page (728-730)
Publication Publié, 1974
Article révisé par les pairs
Résumé : Dantrolene sodium or 1 [5 (p nitrophenyl) furfurylidene amino] hydantoin sodium hydrate (DaNa) is a long acting drug with skeletal muscle relaxant properties which has recently seemed clinically useful in the treatment of some types of muscle hypertonia. DaNa does not affect neuromuscular transmission nor the electrical properties of skeletal muscle and it apparently involves the processes of excitation contraction coupling. The mode of action of DaNa has not been studied before on single muscle fibres and here the authors provide direct evidence that DaNa interferes with the intracellular movements of calcium ions.