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Antithrombin III, plasminogen and alpha2 antiplasmin in jaundice. Clinical usefulness and prognostic significance

par Rodzynek, Jean-Jacques ;Urbain, Daniel ;Leautaud, Pierre;Wettendorff, Pierre ;Delcourt, André
Référence Gut, 25, 10, page (1050-1056)
Publication Publié, 1984

Article révisé par les pairs

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Résumé :

In this prospective study, antithrombin III, plasminogen and alpha2 antiplasmin which are synthetised by the liver were measured and compared with the Normotest, Thrombotest and fibrinogen concentrations in 92 consecutive jaundiced patients. Antithrombin III appeared to be the most discriminant coagulation test in differentiating hepatocellular from cholestatic jaundice. A high correlation was observed between antithrombin III, plasminogen alpha2 antiplasmin values suggesting that the liver synthesis of these parameters was closely linked. The prognostic significance of the blood coagulation tests in patients with jaundice has been studied. In parenchymatous liver disease, antithrombin III, plasminogen and alpha2 antiplasmin were superior to the Normotest, Thrombotest and fibrinogen concentration in predicting the prognosis of the patients at the time of admission. In cholestatic jaundice, however, none of the blood coagulation tests studied had a prognostic significance.