Article révisé par les pairs
| Résumé : | Using a new biomathematical model recently proposed to calculate, from glomerular sieving data for PVP125I, the pores radius (r) and the total area per unit of path length (AP/ΔX) i.e. the parameters characterizing the permeability of an ideal isoporous equivalent membrane, a mean value for the effective glomerular filtration pressure (GFPe) in the dog has been derived from Poiseuille's law. The effects of the intra arterial perfusion of acetylcholine have been studied. As a mean r decreased by 5%, AP/ΔX decreased by 35% while GFPe increased by 60% in the perfused kidney. The same effects have been noticed but less pronounced in the controlateral kidney. These changes are accompanied by an increase in effective renal plasma flow but without modification of glomerular filtration rate (GFR). The significance of these results as far as GFR autoregulation is concerned, is discussed. |
