Article révisé par les pairs
Résumé : IT has been suggested that a defect of acetylcholine synthesis in motor nerve endings would account best for the peculiar features of neuromuscular block seen in myasthenic patients1. This hypothesis can be tested by investigating the effect on the skeletal muscle of the cat of a recently developed drug2, hemicholinium base HC3, which strongly inhibits the synthesis of acetylcholine by nervous tissue3. © 1958 Nature Publishing Group.