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Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of NF-kB and endoplasmic reticulum stress

par Kharroubi, Ilham ;Ladrière, Laurence ;Cardozo, Alessandra K ;Dogusan, Zeynep ;Cnop, Miriam ;Eizirik, Decio L.
Référence Endocrinology, 145, page (5087-5096)
Publication Publié, 2004

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Titre:	Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of NF-kB and endoplasmic reticulum stress
Auteur:	Kharroubi, Ilham; Ladrière, Laurence; Cardozo, Alessandra K; Dogusan, Zeynep; Cnop, Miriam; Eizirik, Decio L.
Informations sur la publication:	Endocrinology, 145, page (5087-5096)
Statut de publication:	Publié, 2004
Sujet CREF:	Médecine clinique [biologie clinique]
MeSH keywords:	Animals
	Apoptosis -- drug effects
	Apoptosis -- physiology
	Carcinogens -- pharmacology
	Cell Line, Tumor
	Cytokines -- pharmacology
	Drug Synergism
	Endoplasmic Reticulum -- metabolism
	Fatty Acids, Nonesterified -- toxicity
	Flow Cytometry
	Insulinoma
	Interferon-gamma -- pharmacology
	Interleukin-1 -- pharmacology
	Islets of Langerhans -- cytology
	Islets of Langerhans -- drug effects
	Islets of Langerhans -- metabolism
	Male
	NF-kappa B -- metabolism
	Oleic Acid -- toxicity
	Palmitates -- toxicity
	Pancreatic Neoplasms
	Rats
	Rats, Wistar
	Thapsigargin -- pharmacology
	Tumor Necrosis Factor-alpha -- pharmacology
Note générale:	Journal Article
	Research Support, Non-U.S. Gov't
Langue:	Anglais
Identificateurs:	urn:issn:0013-7227
	info:doi/10.1210/en.2004-0478
	info:pii/en.2004-0478
	info:scp/9244231766
	info:pmid/15297438
	cm-0040