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The effect of X-rays and ultraviolet light on the uptake in vitro of [8-14C]adenine and [2-14C]-phenylalanine by isolated nuclei

par Logan, Robert;Errera, Maurice Leo ;Ficq, Adrienne
Référence Biochimica et biophysica acta, 32, C, page (147-155)
Publication Publié, 1959

Article révisé par les pairs

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Résumé :

1. 1. The uptake of [8-14C]adenine and [2-14C]phenylalanine into isolated calfthymus nuclei have been shown to be inhibited by X-irradiation. 2. 2. X-irradiation of isolated calf-thymus nuclei inhibited the uptake of [14C]adenine into the nuclear RNA while the uptake into the DNA was unaffected. 3. 3. X-irradiation of isolated rat liver nuclei and/or microsomes inhibited the uptake of [14C]adenine by the nuclei. u.v. irradiation of the nuclei and/or the microsomes, in this system, gave rise to an inhibition of adenine uptake which was reversed by incubating in daylight. 4. 4. X-irradiation of isolated rat-liver nuclei and/or mitochondria inhibited the uptake of [14C]phenylalanine by the nuclei. u.v. irradiation of the nuclei and/or the microsomes, in this system, gave rise to an inhibition of phenylalanine uptake which was reversed by incubating in daylight. © 1959.