par Chantrenne, Hubert ;Devreux, Suzanne
Référence Biochimica et biophysica acta, 39, 3, page (486-499)
Publication Publié, 1960-04
Article révisé par les pairs
Résumé : In the presence of 8-azaguanine, protein synthesis is strongly inhibited and the formation of constitutive penicillinase is completely abolished. Low concentrations of azaguanine which are sufficient to block penicillinase formation do not change the rate of DNA synthesis. Higher concentrations cause an initial slight inhibition which becomes much stronger after about one doubling of the DNA. Azaguanine increases the rate of RNA formation while being incorporated into RNA. At low concentration the analogue is incorporated for a limited time only; later a large part of it is rejected from the RNA. The RNA of bacteria which have incorporated azaguanine is more labile in acid medium than normal RNA. The effects of azaguanine on B. cereus resemble those of chloramphenicol on E. coli and S. aureus. © 1960.