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Rat chromosome 2: assignment of the genes encoding cyclin B1, interleukin 6 signal transducer, and proprotein convertase 1 to the Mcs1-containing region and identification of new microsatellite markers

par Szpirer, Claude ;Tissir, F.;Riviere, Michèle ;Van Vooren, Pascale ;Kela, J.;Lallemand, Françoise;Gabant, Philippe ;Hoebee, Barbara;Klinga-Levan, Karin;Levan, Göran;Szpirer, Josiane
Référence Mammalian Genome, 10, page (30-34)
Publication Publié, 1999

Article révisé par les pairs

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Résumé :

The rat Chromosome (Chr) 2 harbors several genes controlling tumor growth or development, blood pressure, and non-insulin-dependent diabetes mellitus. We report that the region (2q1) containing the mammary susceptibility cancer gene Mcs1 also harbors the genes encoding cyclin B1, interleukin 6 signal transducer (gp130), and proprotein convertase 1. We also generated 13 new anonymous microsatellite markers from Chr 2-sorted DNA. These markers, as well as a microsatellite marker in the cyclin B1 gene, were genetically mapped in combination with known markers. A cyclin B1-related gene was also cytogenetically assigned to rat Chr 11q22-q23.