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Interferon-γ-activated immature macrophages exhibit a high Trypanosoma cruzi infection rate associated with a low production of both nitric oxide and tumor necrosis factor-α

par Plasman, Nathalie;Metz, Gaëtane ;Vray, Bernard
Référence Parasitology research, 80, 7, page (554-558)
Publication Publié, 1994

Article révisé par les pairs

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Résumé :

Murine peritoneal macrophages (MPM) can be subdivided into two subpopulations of mature and immature macrophages. In contrast to mature macrophages, immature ones were highly susceptible to Trypanosoma cruzi infection. This high susceptibility was associated with a low production of α2-macroglobulin. Interferon-γ (IFN-γ)-activated immature macrophages also exhibited a higher infection rate than did IFN-γ-activated mature ones. This higher rate of infection was associated with a low production of both nitric oxide (N=O) and tumor necrosis factor-a (TFN-α). In contrast, mature MPM showed a lower rate of infection and produced higher levels of N=O and TFN-α. Taken together, these results show a clear-cut difference in the course of T. cruzi infection in relation to the macrophage maturation state.