par Deleers, Michel 
;Guilmin, T;Laduron, Chantal;Ruysschaert, Jean Marie
Référence Journal of colloid and interface science, 90, 1, page (229-232)
Publication Publié, 1982-11
;Guilmin, T;Laduron, Chantal;Ruysschaert, Jean Marie Référence Journal of colloid and interface science, 90, 1, page (229-232)
Publication Publié, 1982-11
Article révisé par les pairs
| Résumé : | The influence of stearylamine upon the behavior of unilamellar liposomes formed from dimyristoyl, dipalmitoyl, and distearoyl phosphatidylcholine was investigated. In the presence of stearylamine, optical density measurements indicated that larger liposomal structures are formed. However, when stearylamine was incorporated in distearoyl phosphatidylcholine, i.e., when a stearoyl chain was present in both components of the liposome, no change could be detected. Differential scanning calorimetry of the different liposomal suspensions revealed that for the different systems used, new liposomal structures were formed. The kinetics of transformation depends strongly on the chemical structure of the lipid and of the amine. The possible change in physicochemical properties of the liposome due to the incorporation of a lipid-soluble compound should be kept in mind in any attempt to use liposomes as pharmacological capsules. © 1982. |
