par Stevens, Etienne
;Roman, Alain
;Houa, Myriam
;Razavi, Darius
;Jaspar, Nadine 
Référence Intensive care medicine, 24, 4, page (369-371)
Publication Publié, 1998





Référence Intensive care medicine, 24, 4, page (369-371)
Publication Publié, 1998
Article révisé par les pairs
Résumé : | We recently observed a 45-year-old patient with a history of psychiatric illness who presented with severe hyperthermia (rectal temperature above 41°C) with intense rhabdomyolysis and liver cytolysis during tetrabenazine therapy for neuroleptic tardive dyskinesia. In addition to tetrabenazine, this patient took lorazepam and two antidepressant drugs: clomipramine, a potent serotonin-reuptake inhibitor, and mianserin. Hyperthermia responded to parenteral sodium dantrolene and oral bromocriptine administration. The significant role of tetrabenazine (a central nervous system dopamine-depleting drug) and the contribution of antidepressants to the mechanism of this neuroleptic malignant syndrome-like hyperthermia are discussed. |