par Boogaerts, Jean 
;Declercq, Anne;Lafont, Noëlle ;Benameur, H.;Akodad, El Mustapha ;Dupont -, Jerôme J.C.;Legros, Franz Jacques
Référence Anesthesia and analgesia, 76, 3, page (553-555)
Publication Publié, 1993
;Declercq, Anne;Lafont, Noëlle ;Benameur, H.;Akodad, El Mustapha ;Dupont -, Jerôme J.C.;Legros, Franz Jacques Référence Anesthesia and analgesia, 76, 3, page (553-555)
Publication Publié, 1993
Article révisé par les pairs
| Résumé : | The acute central nervous system and cardiac toxicities of 0.25% bupivacaine, without adrenalin, encapsulated in multilamellar liposomes were compared with 0.25% plain solutions with and without adrenalin after intravenous infusion at a rate of 0.15 mg · kg-1 · min-1 with an increase of 0.035 mg · kg-1 · min-1 every 10 min. Three groups of six anesthetized, unventilated rabbits were studied. The doses of bupivacaine (in mg · kg-1) which produced seizure, ventricular tachycardia, and asystole were determined. The doses of bupivacaine inducing seizure and ventricular tachycardia were significantly higher for liposomal bupivacaine than for the two plain solutions. A statistical comparison of the cumulative lethal doses of bupivacaine 0.25% with adrenalin and of liposomal bupivacaine led to a P = 0.06. Adrenalin did not modify the systemic toxicity of the local anesthetic. This study showed a reduction of nervous and cardiac toxicity of bupivacaine encapsulated in multilamellar liposomes when infused intravascularly. |
