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Transfer RNA modification: influence on translational frameshifting and metabolism.

par Björk, G R;Durand, J.M.;Hagervall, T G;Leipuviene, R;Lundgren, H K;Nilsson, Kenneth;Chen, P;Qian, Q;Urbonavicius, Jaunius
Référence FEBS letters, 452, 1-2, page (47-51)
Publication Publié, 1999-06

Article révisé par les pairs

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Résumé :

Transfer RNA modification improves the rate of aa-tRNA selection at the A-site and the fitness in the P-site and thereby prevents frameshifting according to a new model how frameshifting occurs [Qian et al. (1998) Mol. Cell 1, 471-482]. Evidence that the presence of various modified nucleosides in tRNA also influences central metabolism, thiamine metabolism, and bacterial virulence is reviewed.