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Cooperation between the thyroid hormone receptor TRalpha1 and the WNT pathway in the induction of intestinal tumorigenesis.

par Kress, Elsa;Skah, Seham;Sirakov, Maria ;Nadjar, Julien;Gadot, Nicolas;Scoazec, Jean-Yves;Samarut, Jacques;Plateroti, Michelina
Référence Gastroenterology, 138, 5, page (1863-1874)
Publication Publié, 2010-05

Article révisé par les pairs

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Résumé :

Colorectal tumorigenesis is a multistep process involving the alteration of oncogenes and tumor suppressor genes, leading to the deregulation of molecular pathways that govern intestinal homeostasis. We have previously shown that the thyroid hormone receptor alpha1 (TRalpha1) controls intestinal development and homeostasis through the WNT pathway. More precisely, TRalpha1 directly enhances the transcription of several components of this pathway, allowing increased expression of beta-catenin/Tcf4 target genes and stimulation of cell proliferation. Because the WNT pathway is a major player in controlling intestinal homeostasis, we addressed whether the TRalpha1 receptor has tumor-inducing potential.