par De Backer, Daniel 
;Vincent, Jean Louis
Editeur scientifique Baue, Arthur E.;Berlot, Giogio;Gullo, Antonino
Référence Sepsis and Organ Dysfunction, Epidemiology and Scoring Systems Pathophysiology and Therapy, Springer, Milan, page (123-130)
Publication Publié, 1998
;Vincent, Jean Louis Editeur scientifique Baue, Arthur E.;Berlot, Giogio
;Gullo, AntoninoRéférence Sepsis and Organ Dysfunction, Epidemiology and Scoring Systems Pathophysiology and Therapy, Springer, Milan, page (123-130)
Publication Publié, 1998
Partie d'ouvrage collectif
| Résumé : | Recent studies [1, 2] have implicated the hepato-splanchnic area in the development of multiple organ failure. Important alterations can take place in the gut and the liver during sepsis, A decreased gastric intramucosal pH (pHi), thought to reflect inadequate gut perfusion, is often encountered in sepsis and is associated with increased mortality rates [3, 4]. Liver dysfunction is also common in sepsis and alterations in liver blood flow may contribute to it. The hepatic venous oxygen saturation (ShO2) is often decreased [5-9], reflecting an imbalance between oxygen demand and supply in the hepato-splanchnic area. Also, the liver could be a major source of cytokine release [10], possibly triggered by hypoxia. |
