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The action of ribonuclease on sensitive and non-induced lysogenic cells of Bacillus megaterium.

par Jeener, Raymond
Référence Biochimica et biophysica acta, 32, 1, page (99-105)
Publication Publié, 1959-03

Article révisé par les pairs

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Résumé :

The rate of protein synthesis in Bacillus megaterium is decreased by ribonuclease under conditions where no cellular lysis occurs although the ratios existing between RNA, DNA and protein content of the cells are unaffected. Moreover, the same relation exists in control and in RNase-treated cells between uptake of [14C]adenine in RNA and net RNA synthesis. Nevertheless, the decrease of protein synthesis is accompanied by a modification in the base ratios of the RNA, an increase in cell volume and an irreversible and extensive decrease of the capacity of the cells to undergo several successive multiplications. A hypothesis is put forward concerning the action of RNase which takes these facts into account. © 1959.