par Brachet, Jean ;Cape, Marianne ;Decroly, Marc ;Six, Nicole
Référence Biochimica et biophysica acta, 51, page (347-356)
Publication Publié, 1961-08
Article révisé par les pairs
Résumé : Some biochemical effects of β-mercaptoethanol on the liver of mouse and rat The effects of β-mercaptoethanol (HSCH2-CH2OH) on the biochemistry of mouse and rat liver have been studied both in vivo and in vitro. It has been found that intraperitoneal injection of mercaptoethanol has no appreciable effect on the soluble-SH, ATP, DNA and RNA content of the cells. On the other hand, mercaptoethanol exerts a very definite inhibitory effect on the incorporation of labelled amino acids into liver proteins both in vivo and in vitro (30-40% inhibition). Mercaptoethanol, if injected in vivo, does not set free one of the enzymes characteristic of lysosomes, acid phosphatase; there is no liberation either of acid phosphatase when a particulate fraction containing the lysosomes is treated by mercaptoethanol in vitro. The meaning of these results is discussed. © 1961.