Binding of tritiated actinomycin and cell differentiation

Brachet, Jean; Lacroix-Hulin, Nicole

doi:doi/10.1038/222481a0

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Binding of tritiated actinomycin and cell differentiation

par Brachet, Jean

;Lacroix-Hulin, Nicole

Référence Nature (London), 222, 5192, page (481-482)
Publication Publié, 1969-05

Article révisé par les pairs

Résumé :

CHANGES in the degree of resistance of DNA to acid hydrolysis have been demonstrated during spermatogenesis and early embryonic development1. These changes can be demonstrated by a cytophotometric study of the kinetics of the Feulgen reaction in the nuclei of different parts of the neurula, the larval chondrocytes and erythrocytes, spermatocytes, spermatids and spermatozoa. It is not easy, however, to give an exact biochemical explanation of these variations; results merely suggest that the binding of DNA to various proteins, which might be important in the control of genetic transcription, could vary from one cell type to another. © 1969 Nature Publishing Group.

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